Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes.

Region-Restricted Antigen Presentation to T Antigen-Processing Event Required for I- Pillars Article: Identification of a Macrophage

The role of I region gene products in macrophage - T lymphocyte interaction.

The macrophage first gained recognition in the early 192O's and 193O's as the cell responsible for clearing antigen and synthesizing antibody (Sabin 1923). Its importance to the immune response faded with the realization that lymphocytes and not macrophages were the origin of antibody molecules and it was not until the early 196O's that experiments suggested that antigen processing by the macro...

Evidence for the Presentation of Major Histocompatibility Complex Class I–restricted Epstein-Barr Virus Nuclear Antigen 1 Peptides to CD8+ T Lymphocytes

The Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) is expressed in all EBV-associated tumors, making it an important target for immunotherapy. However, evidence for major histocompatibility complex (MHC) class I-restricted EBNA1 peptides endogenously presented by EBV-transformed B and tumor cells remains elusive. Here we describe for the first time the identification of an endogenou...

An early event in murine cytomegalovirus replication inhibits presentation of cellular antigens to cytotoxic T lymphocytes.

Cytomegalovirus (CMV) infection of simian virus 40 (SV40)-immune mice inhibits priming of SV40-specific helper and cytotoxic T lymphocytes (CTL) in vivo (A. E. Campbell, J. S. Slater, and W. S. Futch, Virology 173:268-275, 1989; J. S. Slater, W. S. Futch, V. J. Cavanaugh and A. E. Campbell, Virology 185:132-139, 1991). We now demonstrate that murine CMV (MCMV) infection of SV40-transformed macr...

Cellular mechanisms of abscess formation: macrophage procoagulant activity and major histocompatibility complex recognition.

BACKGROUND Macrophage procoagulant activity (PCA) has been proposed as a key mediator of abscess formation. Experimentally, transient systemic bacterial infection lead to increased numbers of intraabdominal abscesses after a subsequent episode of peritonitis. We tested the hypothesis that these events were regulated by classic major histocompatibility complex (MHC)-restricted antigen processing...